This is the opposite of the experience people have when googling symptoms, though, where you often find articles suggesting that you’ve got some very serious condition when you do not. Interesting that the human bias when reading WebMD type articles is the opposite of the bias of LLMs.
That's not universal. I work in genetics, and we did an investigation a few months back, by asking various AIs whether a particular mutation causes $DISEASE. Invariably they were very strongly biased towards saying yes, even for completely obviously benign variants. I think that's because the majority of the literature out there describing variants is describing pathogenic ones, because why would you write an article about a benign variant, so the only material it has ingested is articles describing variants as pathogenic. In reality, the average person has millions of variants, and almost all of them are completely benign, so there should be a very strong pre-supposition that a given variant is benign unless there is fairly strong evidence saying otherwise.
You were asking about individual mutations, like SNPs or small indels?
Very few diseases are caused by individual mutations like that (typically only monogenic Mendelian). Individual mutations typically cause an increased propensity, or severity, rather than being the sole or root cause of a disease.
I work with monogenic diseases, where a single mutation (or a pair in the same gene for recessive conditions) does cause disease. There's a lot of them. Your statement isn't true for these.
You're talking about polygenic traits. That's a different ball game entirely.
Sorry, I should have said: the preponderance of people with disease suffer from (a small number of) polygenic trait diseases, while if you sum up all the monogenic diseases, it's a smaller number of people with disease by far. You're correct that there are many monogenic diseases but the vast majority of them are extremely rare.
In short, if you solve a monogenic disease you help maybe 20-30 million worldwide (and then you have to solve other ones), if you solve CVD,type 2 diabets, hypertension- each of those is 500+M people. So in general, we would expect to have more impact with polygenic, although they tend to be far harder to treat because of the complexity.
True! However, don't both biases point to "don't (primarily) decide by googling or asking an LLM"? You'll either be extremely scared or extremely reassured.
Wow, that is a seriously impressive demo. I wonder how it’s able to distinguish people using identical hardware and software versions (e.g., iPhones on the same iOS version). It was able to correlate my sessions across multiple independent ISPs, with a VPN, and with Apple’s extra tracking resistance in private mode.
That is expensive. If it makes you feel better, U.S. utilities' published kWh rates don't include a whole bunch of other things that make bills much higher than you'd imagine. For example, I used 280 kWh last month for my apartment, at a nominal rate of either 11 or 13 c/kWh (the rate changed from 13 to 11 partway through the month as it got cooler).
But after all the "sales true ups" and "affordability charges" and "resource adjustments" and "fuel cost charges" and "interim rate adjustments", not to mention the city fees and sales tax, the final bill divided by my usage gave me an effective rate of 23 c/kWh.
That sounds horrible, even in Europe deceptive and abusive tactics towards taking people's money are a constant hazard. I can't imagine trying to exist without even what little protection we have.
Utilities are actually highly regulated in the US. Those rates and fees are publicly available and explained when you get your service, for what it’s worth.
Utilities have to argue for rate increases and get them approved by regulators, so they’re not just dropping fees on top of everything as they please from month to month.
Really nobody should assume that their service is flat rate with a slope down to $0/month if you consume 0kWh. There are fixed and marginal costs in every service like this.
> Utilities have to argue for rate increases and get them approved by regulators, so they’re not just dropping fees on top of everything as they please from month to month.
Do regulators ever reject rate increases that the utilities ask for?
There is a state utility regulator that is supposed to ensure this stuff is fair, and it is disclosed ahead of time. Regardless, for small energy users like me, the fixed costs and extra fees are a huge percentage of the total. Thankfully the total electricity bill is not terribly consequential for my household budget.
No, I just use the one at work when needed. I encouraged my parents to get the absolute cheapest Brother laser printer, which has worked great for a lot of years at a very reasonable cost (both for the printer and per page).
> “There’s about a 50% chance we all die because of the development of smarter-than-human AI systems,” he said, adding that actions taken over the next two to 10 years would be decisive.
What’s the mechanism by which this happens? I feel like people making these predictions live on a different planet.
The "mechanism" is that some stupid rich and/or powerful person who believes they're smarter than all the world's experts combined will do something unbelievably stupid, like give one of these "AI" things too much access, control, or power without sufficient safety measures in place and bring about some massive catastrophe that pushes humanity straight into extinction.
I hope what they offer is the ability to set more granular rules, like allowing my Borg backup script to access the whole disk, but not any random Git precommit hook (for example). Given that practically all of the existing restrictive security features on macOS (for example, SIP) can be disabled, I feel confident that Apple will make hobbyist and professional use cases still possible, just requiring some extra scary messages. I’m ok with that trade off.
You can play Factorio on laptops and other devices that don’t have dedicated GPUs. A mid-grade computer from 2013 would be a $599 laptop with a Core i3 integrated GPU that shared the 4 GB of system RAM.
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