Going from cable to streaming was a net increase in advertising because now the providers can make ads unskippable. (Also the ads are hypertargeted now.)
Going from traditional search to AI will echo that net worsening of ad-related user experience. The net surveillance is also greater because logged-out search will go away.
Maybe there's a general lesson that successive generations/disruptions of technology seem better at first but end up qualitatively worse.
We rightly restrict tobacco advertising because freedom to advertise is balanced with and does not always trump public health. Rights and responsibilities are not absolute, they exist in a complex tapestry of priorities.
A side effect of rapid technological change is that there are now multiple generations who didn't experience the pre-monetized internet.
It's like we've hit a tipping point where enshittification etc. are allowed to thrive because there's no longer a critical mass of people who know from first-hand experience that things don't have to be this bad.
It's become easy to pacify young people with the meme that older people didnt really have a better internet, they're remembering the past as better than it actually was.
People will eventually realize that they've become dependent on an increasingly expensive and worsening AI subscription in a way that echoes the worsening and rising costs of streaming services.
But the impact of depending on the tech giants for search and cognition and job skills will be significantly greater.
Why will employers five years from now pay for your $300 AI subscription when there exist other candidates who will absorb the cost themselves?
I think the important bit is that, from my understanding, mouse models of alzheimer's dont translate as reliably to humans as it does for other diseases
This is correct, mice don’t naturally experience alzheimer’s or other dementias during their lifespans and the structure of their amyloid beta protein is different as well. To continue using them as model organisms, we have to induce the disease in them by either introducing human genes that are linked with alzheimer’s, or chemically inducing a disease state that we believe to be similar. Mice are much better models organisms for studying metabolism or cancer, by comparison.
It's utterly unimportant. It's all research and all progress and all works towards our benefit eventually. The fact that an important discovery is still in the mouse stage and not yet in the human stage doesn't make it any less important or interesting, unless you are unutterably simple.
Put another way: the "in mice" doesn't matter because they are studying alzheimers, not mice. the mice are just the lab equipment of the moment. I don't care what kind of glassware or computers they use either.
It depends on what's being studied. There are mice studies on diet which obviously don't carry over to human beings since we don't have similar digestive systems. It may be true (arguable) that all research data is of some benefit, but don't expect people to be as excited about mouse research as human research.
How do they get the alzheimers mice? Article doesn't say. Usually in studies they take healthy mice and induce the condition artificially. That can be a confounding factor since the condition isn't induced in the specimens we care about (human beings). Is it even the same condition?
It doesn't matter how they give mice alzheimers, or any other condition. That's just part of controlling variables to test for one thing. It also doesn't matter that they were fed processed food rather than having to find things in the wild, unless the effect of diet was the specific thing they were examining.
It does not matter how they give Alzheimer's to a lab mouse providing they give Alzheimer's to a lab mouse – not a different disorder that happens to have the symptoms of Alzheimer's.
If this was a website for fundamental biology research I’d agree.
As it stands, the headline is misleading and clickbaity.
> the "in mice" doesn't matter
Of course it matters, because that has a direct bearing on how applicable it is to humans and how much time it’s likely to take to be of any benefit to humans, if it ever is. That’s the whole point being discussed.
Also see this comment to help understand why “in mice” is a huge qualifier in this case, because mice don’t naturally develop Alzheimer’s: https://news.ycombinator.com/item?id=50218606
The "... in mice" qualifier is somewhat overdone, but for Alzheimer's in particular, it's actually extremely important: mice do not experience Alzheimer's. We test Alzheimer's drugs in mice by artificially inducing something that produces similar dementia symptoms, and then seeing how the drugs influence that progression. If that model is different from how Alzheimer's works--and there's pretty decent suggestions from the history of failed Alzheimer's drugs in humans that our models of Alzheimer's are in fact wrong--then anything that fixes that model has suspect utility.
Social media has become so terrible in the last few years that I've grown to depend on it less without even making an effort to. I deleted my accounts on the worst sites and only visit anonymously, which has trailed off over time. I've joined newer/better sites but haven't let myself get attached to them. If they go away it won't feel like a big loss.
In that respect, the worsening of social media has been a gift. I'm still online but with the attitude of: "Don't ever let yourself get attached to anything you are not willing to walk out on in 30 seconds flat if you feel the heat around the corner."
I would never be expected to clean my dishes after ordering room service in a hotel. The price of an AirBNB would have to be much cheaper than a hotel in order for me to do my own cleaning. And in my city at least, it never was.
but you are paying extra for the room service. the price pf washing is included in that. when i bring my own food then i totally expect to clean the dishes i use from the host myself.
ok, yes, it depends how high the cleaning fee is. and i would also consider what is normal usage.
for example if i spend a several days or longer in a place and instead of washing and reusing dishes as i would at home, i never wash any dishes but use up all the available dishes instead then i would not consider that normal.
dirty dishes also contain leftover food which can rot, or dry up, making it hard to clean, etc, you don't want to leave that stuff out for to long.
bed sheets on the other hand i wouldn't wash unless i am there long enough that i want to reuse them myself. the rest is just keeping things tidy and not leave chaos behind.
or they factored the cost of cleaning into their price. doing the cleaning as a host myself is not a reason not to charge a cleaning fee if that is the way i make my money.
the whole thing with a cleaning fee is either to allow the advertised room price to appear lower (but doesn't airbnb now factor the cleaning fee into the price shown?) or alternatively to make longer stays cheaper because the cleaning fee is not applied for every day).
Ironically (or fittingly) given that origin, the Xbox version of the Plex app may be the best one to use now because it's been abandoned and was never updated to the terrible redesign.
Going from traditional search to AI will echo that net worsening of ad-related user experience. The net surveillance is also greater because logged-out search will go away.
Maybe there's a general lesson that successive generations/disruptions of technology seem better at first but end up qualitatively worse.
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