I prefer to let uBlock handle all the blocking. Also I run my own DNS server where I have my own blocklists and internal records etc.

I run a local DNS server that has its own blocklists, internal DNS records, etc. I imagine most people who might bother to deploy an enterprise browser policy do something similar.

I find it most useful for a shared family computer with multiple users, but I also appreciate any type of config-as-code where possible

I think most people use an enterprise MDM like JAMF or Intune, but manually creating the file at /Library/Managed Preferences/com.google.Chrome.plist might also work.

There are some wandering sages who still practice the old ways.