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Not a joke at all. It is well documented. Attention peaks a few hour after you wake up then it's all downhill from there. It seems counterintuitive, but somebody working at full capacity for "only" 4h a day can be more efficient that somebody working 12h every day (of course, these all ballpark numbers and depend on a lot of factors, sleep being one of the most crucial one).

I don't see how this would have been different is the author of the paper had used Google to get their fake stats published instead.

Yes, it is deceptively easy to post fake information on the internet, and with social media and AI, it is even easier to spread them.

I wonder however, would prompting a LLM to use only reliable sources return the fake stats website?


Disclaimer: I did not work in protein design but in biophysics. However some of my collaborators did.

It definitely is a small help. Although the lab I was working with had supercalculators to generate microtubule-binding proteins, They were kind of limited in how many they could simulate and try, so being able to go through 318K molecules is useful. Our lab was then tasked with doing the testing (I designed the automated assay) and this part is going on right now, I expect it to last around a year (small lab, many tests to run).

Once potential medical targets have been found, the actual work takes several years as you have mentionned as you would switch to cell cultures, then animal models, then human trials. That matches the 6-7 years timeline you mentionned.

So overall, you can crunch a ~6-months period into 1 month, which is definitely a time saver.


As a former drug discovery scientist I agree with the “small help” conclusion.

Find “potential leads” is something we did plenty of with computational chemistry. We’d get leads that we a “slam dunk” and they’d fail horribly in clinical trials.

Finding leads is easy, finding leads that reliably pan out in the lab is not


My favorite is mustard rabbit (Lapin à la moutarde). It's basically rabbit stewed in white wine, cream or butter and mustard. Mustards helps make a really thick sauce and you can use a copious amount since its flavor mellows down when you cook it.

The "not bothering to check" part is the most annoying.

There are already several of these "proofs" that have been retracted because they did not make sense.

I would have no problem accepting this whole ordeal if the humans behind each proof took the time to re-read, understand and synthesize the result in a readable paper.

There is ample evidence of how damaging fake information can be, and paper retraction never fully undoes the damage (see the Andrew Wakefield and his antivax "paper" for instance).


Same sentiment here.

I always wondered why so much of discussed politics centers around race and gender, but I think this is a good hypothesis.

"More generally, you can have a fruitful discussion about a topic only if it doesn't engage the identities of any of the participants."


I think the more interesting result you provided is kind of buried in the article: after you re-word the question and put the negative consequences of pulling the lever, the models switch decision.

This has always been obvious to me, but I wish more people would understand this: uncalibrated decision models are basically worthless. The model clearly doesn't "understand" the semantics of the question since the result heavily depends on how you word it.

It is nothing new thought. Before that, a lot of people would ask LLM for confidence scores while classifying text (I even saw a paper from a team at Google).

So with that in mind, I really don't get the hype behind decision models. If you need to curate a dataset to build a classifier anyway, why not train it yourself and have an even faster model?


It really depends on your teeth layout.

If you are lucky enough to have very straight and packed teeth, there is very little room between your teeth for any food to be lodged in. I used to never floss then one day I tried it and it took me 3 weeks of flossing before the wire came out clean and odorless.


https://harnesstax.github.io/

From what I gathered, a simple harness like the one from Pi is sufficient.

Similarly, I would advise against using tons of skills and keep the ones you genuienly find useful (they are just .md files so you can copy them). The only skill I use is /strategic-compact from everything claude code (ecc) because I like to read the summary before a manual compaction.


It's definitely my favorite from Slovakia. Definitely made even more delicious with halušky.

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