Give it 3 years and an acquisition offer of billions by Mastercard or Visa

Really good news for Italy and for the whole of Europe (if not the world)!

The atomic revival of Europe

Seems like COVID changed us

The article states the decline began in the mid 2010s. Covid may have sped things along but it wasn't the cause.

Agreed. I did not mean that covid was the cause. The chart shows that it was a significant change

Consti, this could do well on IG and TikTok.

Love the take on AI

Thanks! I'm not much of a social media person (went so far that I made an Apple shortcut app to launch IG in the messages screen[0], so I can avoid the feed). But maybe I'll try to post something there.

[0] just open the URL instagram://direct-inbox

Have you noticed that google slides has autoplay? You can even select how many seconds you want

Interesting, will try it!

We are very early in the semaglutide world, exciting times ahead!

For sure we still need to find out many related outcomes.

Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss.

https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

To save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes.

Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's.

I didn't check to see if other studies prove that.

It is well known that forcing a sudden drop in chronically high average blood glucose (like, from 200+ to a normal ish range) with insulin can cause vision loss. I wonder if it's the same mechanism?

It tends to happen when:

1) You must have a crowded optical disc as a precursor (low cup to disc ratio). Genetic and can be tested

2) You have stiff veins/arteries due to poor metabolic/cardio health

3) when blood pressure drops too much, blood flow can get cut off to the optical nerve temporarily due to reliance on high blood pressure due to 2

4) Due to loss of blood flow, optic nerve swells and closes blood flow into the eye due to 1

It's also true that having a crowded optical disc is pretty much a required precursor condition to suffering NAION.

Which you can get checked for via a $50 optical scan.

No crowded disc, very little risk.

(Cup to Disc ratio of 0.2ish or less starts to present risk)

In addition to being closely associated with the conditions semaglutide treats, NAION is quite rare.

If it reduces inflammation and causes weight loss, I find it impossible to believe you can just stop and not get rebound on both.

Which to me just sounds like every other addictive drug. Paradise while you’re high, and eventually you pay for it.

Or continue to take it.

Finally a company I am qualified to work for, how do I apply?

A break is just not as sellable. We need to call them something different so we can have blog posts and podcasts about them

Baffles me how this is not that well known