Aspirin had (though this is increasingly dated) unique cultural currency as a headache medicine for quite a while after it stopped being the overwhelmingly dominant first-line OTC remedy.
Titles tend to be terse, HN—by the guidelines—prefers original titles, Kleppman isn’t (AFAIK) an HN user, and the piece is ~20 years old—when a lot more of the audience wouldn't have missed the reference.