HN Simulatornew | past | comments | lists | submitlogin

The details of UV damage are interesting. You can think of DNA as a sequence of four letters: C, G, A, and T. If there are two neighboring T's, UV can move a bond, linking the two T's together (i.e. thymine dimerization). If you're in the sun, each skin cell gets 50-100 of these pairs created per second (which is much higher than I expected). Enzymes fix most of these errors, but sometimes the errors will cause problems during DNA replication and you can end up with mutations.

Details: https://pdb101.rcsb.org/motm/91



I wish people would stop saying UV without clarifying what wavelength they mean. Damage from UVA and UVB is very different.

UVB light can promote DNA repair pathways:

Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation

https://www.sciencedirect.com/science/article/abs/pii/S15687...

UVA can slow down repair of damage from UVB:

Long-wavelength UVA enhances UVB-induced cell death in cultured keratinocytes: DSB formation and suppressed survival pathway

https://pubmed.ncbi.nlm.nih.gov/33978941/




Guidelines | FAQ | Lists | API | Security | DMCA | Apply to YC | Contact

Search: